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NEGATIVE EPISTASIS BETWEEN α+ THALASSAEMIA AND SICKLE CELL TRAIT CAN EXPLAIN INTERPOPULATION VARIATION IN SOUTH ASIA
Article first published online: 11 AUG 2011
© 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.
Volume 65, Issue 12, pages 3625–3632, December 2011
How to Cite
Penman, B. S., Habib, S., Kanchan, K. and Gupta, S. (2011), NEGATIVE EPISTASIS BETWEEN α+ THALASSAEMIA AND SICKLE CELL TRAIT CAN EXPLAIN INTERPOPULATION VARIATION IN SOUTH ASIA. Evolution, 65: 3625–3632. doi: 10.1111/j.1558-5646.2011.01408.x
- Issue published online: 1 DEC 2011
- Article first published online: 11 AUG 2011
- Accepted manuscript online: 13 JUL 2011 07:27PM EST
- Received January 31, 2011, Accepted June 13, 2011
- 1964. Polymorphism and natural selection in human populations. Cold Spring Harb. Symp. Quant. Biol. 29:137–149.
- 2002 Sickle cell disease among tribes of Andhra Pradesh and Orissa States, India. Anthropologischer Anzeiger 60:169–174. , , and
- 2006a. Do tribal communities show an inverse relationship between sickle cell disorders and glucose-6-phosphate dehydrogenase deficiency in malaria endemic areas of central-eastern India? HOMO J. Comp. Hum. Biol. 57:163–176.
- 2006b. Genetic heterogeneity of population structure in 15 major scheduled tribes in central-eastern India: a study of immuno-hematological disorders. Ind. J. Hum. Genet. 12:86–92. .
- 1987. Subunit assembly of hemoglobin: an important determinant of hematologic phenotype. Blood 69:1–6.
- 1975. Hemoglobin Koya Dora: high frequency of a chain termination mutant. Am. J. Hum. Genet. 27:81–90. , , and .
- 1999. Appraisal of sickle-cell and thalassaemia genes in Saudi Arabia. Eastern Mediterranean Health J. 5:1147–1153. , and .
- 1998. The population genetics of the haemoglobinopathies. Baillieres Clin. Heamatol. 11:1–51. , , , and .
- 1986. High frequencies of α-thalassaemia are the result of natural selection by malaria. Nature 321:744–750. , , and .
- 1991. Multiple recombination events are responsible for the heterogeneity of alpha-thalassemia haplotypes among the forest tribes of Andhra Pradesh, India. Ann. Hum. Genet. 55:43–50. , , , , , , and .
- 1988. Prevalence and molecular heterogeneity of alpha+ thalassemia in two tribal populations from Andhra Pradesh, India. Hum. Genet. 80:157–160. , , , , , , , , , , and .
- 1995. Dynamic interactions in malaria: host heterogeneity meets parasite polymorphism. Proc. R. Soc. Lond. B 261:271–277. , and .
- 1949. Disease and evolution. Ric. Sci. Suppl: A 19:68.
- 2004. Estimation of relative fitnesses from relative risk data and the predicted future of haemoglobin alleles S and C. J. Evol. Biol. 17:221–224.
- 1991. Common West African HLA antigens are associated with protection from severe malaria. Nature 352:595–600. , , , , , , , , and .
- 1976. Hemoglobin history in West Africa. Human Biol. 48:487–500.
- 2007. Hemoglobin variants and disease manifestations in severe falciparum malaria. J. Am. Med. Assoc. 297:2220–2226. , , , , , , and .
- 2007. Haemoglobin S and haemoglobin C: ‘quick but costly’ versus ‘slow but gratis’ genetic adaptations to Plasmodium falciparum malaria. Hum. Mol. Genet. 17:789–799 , , , , , and .
- 1991. Protection against malaria morbidity: near-fixation of the α-thalassemia gene in a Nepalese population. Am. J. Hum. Genet. 48:390–397. , , , , , , , , , , et al.
- 1990 Field survey for sickle cell disease in the tribal population of East Godavari District, Andhra Pradesh. J. Association of Physicians of India 38:479–481
- 2009. Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean. Proc. Natl. Acad. Sci. USA 106:21242–21246. , , , and .
- 1995. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature 376:246–249. , , , , , , , , , , et al.
- 2009. Genetic differentiation of populations residing in areas of high malaria endemicity in India. J. Genet. 88:77–80. , , , Indian Genome Variation Consortium, and .
- 2001a. Inherited haemoglobin disorders: an increasing global health problem. Bull. World Health Organization 79:704–712. , and .
- 2001b. The thalassaemia syndromes, 4th edn. Blackwell Science, Oxford , United Kingdom . , and .
- 1996. Red blood cell phenotypes in the α+ thalassaemias from early childhood to maturity. Br. J. Haematol. 95:266–272. , , , , , , and .
- 2005a. Sickle cell trait and the risk of plasmodium falciparum malaria and other childhood diseases. J. Infect. Dis. 192:178–186. , , , , , , and .
- 2005b. Both heterozygous and homozygous α+ thalassemias protect against severe and fatal plasmodium falciparum malaria on the coast of Kenya. Blood 106:368–371. , , , , , , and .
- 2005c. Negative epistasis between the malaria-protective effects of alpha + thalassemia and the sickle cell trait. Nat. Genet. 37:1253–1257. , , , , , , , , , , et al.