REDUCED MALE FERTILITY IS COMMON BUT HIGHLY VARIABLE IN FORM AND SEVERITY IN A NATURAL HOUSE MOUSE HYBRID ZONE

Authors

  • Leslie M. Turner,

    1. Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, August Thienemannstrasse 2, 24306 Ploen, Germany
    2. E-mail:lturner3@wisc.edu
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    • Current address: Laboratory of Genetics, 2455 Genetics/ Biotechnology, University of Wisconsin, Madison, WI 53706

  • Denise J. Schwahn,

    1. Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin 53726
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  • Bettina Harr

    1. Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, August Thienemannstrasse 2, 24306 Ploen, Germany
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Abstract

Barriers to gene flow between naturally hybridizing taxa reveal the initial stages of speciation. Reduced hybrid fertility is a common feature of reproductive barriers separating recently diverged species. In house mice (Mus musculus), hybrid male sterility has been studied extensively using experimental crosses between subspecies. Here, we present the first detailed picture of hybrid male fertility in the European M. m. domesticusM. m. musculus hybrid zone. Complete sterility appears rare or absent in natural hybrids but a large proportion of males (∼30%) have sperm count or relative testis weight below the range in pure subspecies, and likely suffer reduced fertility. Comparison of a suite of traits related to fertility among subfertile males indicates reduced hybrid fertility in the contact zone is highly variable among individuals and ancestry groups in the type, number, and severity of spermatogenesis defects present. Taken together, these results suggest multiple underlying genetic incompatibilities are segregating in the hybrid zone, which likely contribute to reproductive isolation between subspecies.

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