THE EFFECT OF DELETERIOUS MUTATIONS AND AGE ON RECOMBINATION IN DROSOPHILA MELANOGASTER
Article first published online: 20 SEP 2011
© 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.
Volume 66, Issue 2, pages 575–585, February 2012
How to Cite
Tedman-Aucoin, K. and Agrawal, A. F. (2012), THE EFFECT OF DELETERIOUS MUTATIONS AND AGE ON RECOMBINATION IN DROSOPHILA MELANOGASTER. Evolution, 66: 575–585. doi: 10.1111/j.1558-5646.2011.01450.x
- Issue published online: 25 JAN 2012
- Article first published online: 20 SEP 2011
- Accepted manuscript online: 26 AUG 2011 05:16PM EST
- Received April 29, 2011, Accepted August 9, 2011, Data Archived: Dryad doi: 10.5061/dryad.t46v2
- condition dependence;
- deleterious mutations;
At the population level, recombination mediates the efficiency with which selection can eliminate deleterious mutations. At the individual level, deleterious alleles may influence recombination, which would change the rate at which linkage disequilibrium is eroded and thereby alter the efficiency with which deleterious alleles are purged. Here, we test whether the presence of a deleterious allele on one autosome affects recombination on another autosome. We find that deleterious alleles not only alter the rate but also the pattern of recombination. However, there is little support that different deleterious alleles affect recombination in a consistent manner. Because we have detailed information on individual females across their lifetimes, we are able to examine how recombination patterns change with age and find that these patterns are also affected by the presence of deleterious alleles. The differences among genotypes or among age classes are large enough to add substantial noise to genetic mapping experiments that do not consider these sources of variation.