REVERSING MOTHER'S CURSE REVISITED
Article first published online: 5 OCT 2011
© 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.
Volume 66, Issue 2, pages 612–616, February 2012
How to Cite
Hedrick, P. W. (2012), REVERSING MOTHER'S CURSE REVISITED. Evolution, 66: 612–616. doi: 10.1111/j.1558-5646.2011.01465.x
- Issue published online: 25 JAN 2012
- Article first published online: 5 OCT 2011
- Accepted manuscript online: 19 SEP 2011 10:01AM EST
- Received June 24, 2011, Accepted August 12, 2011
- maternal inheritance;
- negative-assortative mating;
- positive-assortative mating
Because of maternal mtDNA inheritance, mtDNA mutations detrimental only in males are not expected to be selected against, an effect termed the “mother's curse.” However, if there is positive-assortative mating, equivalent to what was called “inbreeding” by Wade and Brandvain (2009), then selection can act to reduce the frequency of these male-specific detrimental mtDNA mutants. On the other hand, as shown here negative-assortative mating, or “outbreeding, ” paradoxically can result in an increase in the frequency of male-specific detrimental mtDNA mutants. The implications of these findings are briefly discussed.