SPECIFIC INTERACTIONS BETWEEN HOST AND PARASITE GENOTYPES DO NOT ACT AS A CONSTRAINT ON THE EVOLUTION OF ANTIVIRAL RESISTANCE IN DROSOPHILA

Authors

  • Jennifer A. Carpenter,

    1. Institute of Evolutionary Biology, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, United Kingdom
    2.  E-mail: jenny@jennycarpenter.com
    Search for more papers by this author
  • Jarrod D. Hadfield,

    1. Institute of Evolutionary Biology, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, United Kingdom
    Search for more papers by this author
  • Jenny Bangham,

    1. Institute of Evolutionary Biology, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, United Kingdom
    2. Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge CB2 3RH, United Kingdom
    Search for more papers by this author
  • Francis M. Jiggins

    1. Institute of Evolutionary Biology, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, United Kingdom
    2. Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Search for more papers by this author

Abstract

Genetic correlations between parasite resistance and other traits can act as an evolutionary constraint and prevent a population from evolving increased resistance. For example, previous studies have found negative genetic correlations between host resistance and life-history traits. In invertebrates, the level of resistance often depends on the combination of the host and parasite genotypes, and in this study, we have investigated whether such specific resistance also acts as an evolutionary constraint. We measured the resistance of different genotypes of the fruit fly Drosophila melanogaster to different genotypes of a naturally occurring pathogen, the sigma virus. Using a multitrait analysis, we examine whether genetic covariances alter the potential to select for general resistance against all of the different viral genotypes. We found large amounts of heritable variation in resistance, and evidence for specific interactions between host and parasite, but these interactions resulted in little constraint on Drosophila evolving greater resistance.

Ancillary