SPECIFIC INTERACTIONS BETWEEN HOST AND PARASITE GENOTYPES DO NOT ACT AS A CONSTRAINT ON THE EVOLUTION OF ANTIVIRAL RESISTANCE IN DROSOPHILA
Article first published online: 16 DEC 2011
© 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.
Volume 66, Issue 4, pages 1114–1125, April 2012
How to Cite
Carpenter, J. A., Hadfield, J. D., Bangham, J. and Jiggins, F. M. (2012), SPECIFIC INTERACTIONS BETWEEN HOST AND PARASITE GENOTYPES DO NOT ACT AS A CONSTRAINT ON THE EVOLUTION OF ANTIVIRAL RESISTANCE IN DROSOPHILA. Evolution, 66: 1114–1125. doi: 10.1111/j.1558-5646.2011.01501.x
- Issue published online: 6 APR 2012
- Article first published online: 16 DEC 2011
- Accepted manuscript online: 31 OCT 2011 12:37PM EST
- Received August 20, 2010 Accepted September 27, 2011
- Drosophila melanogaster;
- genetic variation;
- genetic variance–covariance matrix;
- host–parasite coevolution;
- sigma virus
Genetic correlations between parasite resistance and other traits can act as an evolutionary constraint and prevent a population from evolving increased resistance. For example, previous studies have found negative genetic correlations between host resistance and life-history traits. In invertebrates, the level of resistance often depends on the combination of the host and parasite genotypes, and in this study, we have investigated whether such specific resistance also acts as an evolutionary constraint. We measured the resistance of different genotypes of the fruit fly Drosophila melanogaster to different genotypes of a naturally occurring pathogen, the sigma virus. Using a multitrait analysis, we examine whether genetic covariances alter the potential to select for general resistance against all of the different viral genotypes. We found large amounts of heritable variation in resistance, and evidence for specific interactions between host and parasite, but these interactions resulted in little constraint on Drosophila evolving greater resistance.