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GENERAL PRINCIPLES OF SINGLE-CONSTRUCT CHROMOSOMAL GENE DRIVE
Article first published online: 9 MAR 2012
© 2012 The Author(s).
Volume 66, Issue 7, pages 2150–2166, July 2012
How to Cite
Marshall, J. M. and Hay, B. A. (2012), GENERAL PRINCIPLES OF SINGLE-CONSTRUCT CHROMOSOMAL GENE DRIVE. Evolution, 66: 2150–2166. doi: 10.1111/j.1558-5646.2012.01582.x
- Issue published online: 3 JUL 2012
- Article first published online: 9 MAR 2012
- Accepted manuscript online: 1 FEB 2012 03:10PM EST
- Received April 21, 2011, Accepted December 21, 2011
- lepidopteron pests;
- population replacement;
- population suppression;
- transgenic mosquitoes
Gene drive systems are genetic elements capable of spreading into a population even if they confer a fitness cost to their host. We consider a class of drive systems consisting of a chromosomally located, linked cluster of genes, the presence of which renders specific classes of offspring arising from specific parental crosses unviable. Under permissive conditions, a number of these elements are capable of distorting the offspring ratio in their favor. We use a population genetic framework to derive conditions under which these elements spread to fixation in a population or induce a population crash. Many of these systems can be engineered using combinations of toxin and antidote genes, analogous to Medea, which consists of a maternal toxin and zygotic antidote. The majority of toxin–antidote drive systems require a critical frequency to be exceeded before they spread into a population. Of particular interest, a Z-linked Medea construct with a recessive antidote is expected to induce an all-male population crash for release frequencies above 50%. We suggest molecular tools that may be used to build these systems, and discuss their relevance to the control of a variety of insect pest species, including mosquito vectors of diseases such as malaria and dengue fever.