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Figure S1. Schematic diagram representing all possible parental crosses and offspring genotypes for a single-construct gene drive system with gender-dependent offspring viability.

Figure S2. Conditions for the spread of an autosomal gene drive construct with gender-dependent offspring viability.

Figure S3. Examples of autosomal constructs for which crosses between TT males and TT females produce no viable offspring (c1 = 0) that spread to gene fixation.

Figure S4. Examples of autosomal constructs for which crosses between TT males and TT females produce no viable offspring (c1 = 0 ) that induce a population crash.

Figure S5. Examples of X-linked constructs for which crosses between XTY males and XTXT females produce unviable male and/or female offspring (c1 = 0 and/or c3 = 0) that spread to gene fixation.

Figure S6. Examples of X-linked constructs for which crosses between XTY males and XTXT females produce unviable male and/or female offspring (c1 = 0 and/or c3 = 0) that induce a population crash.

Table S1. X-linked toxin–antidote constructs that fix in a population despite a fitness cost.

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