• Open Access

THE CONTRIBUTION OF FEMALE MEIOTIC DRIVE TO THE EVOLUTION OF NEO-SEX CHROMOSOMES

Authors

  • Kohta Yoshida,

    1. Ecological Genetics Laboratory, Center for Frontier Research, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411–8540, Japan
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  • Jun Kitano

    1. Ecological Genetics Laboratory, Center for Frontier Research, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411–8540, Japan
    2. PRESTO, Japan Science and Technology Agency, Honcho Kawaguchi, Saitama 332-0012, Japan
    3. E-mail: jkitano@lab.nig.ac.jp
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Abstract

Sex chromosomes undergo rapid turnover in certain taxonomic groups. One of the mechanisms of sex chromosome turnover involves fusions between sex chromosomes and autosomes. Sexual antagonism, heterozygote advantage, and genetic drift have been proposed as the drivers for the fixation of this evolutionary event. However, all empirical patterns of the prevalence of multiple sex chromosome systems across different taxa cannot be simply explained by these three mechanisms. In this study, we propose that female meiotic drive may contribute to the evolution of neo-sex chromosomes. The results of this study showed that in mammals, the XY1Y2 sex chromosome system is more prevalent in species with karyotypes of more biarmed chromosomes, whereas the X1X2Y sex chromosome system is more prevalent in species with predominantly acrocentric chromosomes. In species where biarmed chromosomes are favored by female meiotic drive, X-autosome fusions (XY1Y2 sex chromosome system) will be also favored by female meiotic drive. In contrast, in species with more acrocentric chromosomes, Y-autosome fusions (X1X2Y sex chromosome system) will be favored just because of the biased mutation rate toward chromosomal fusions. Further consideration should be given to female meiotic drive as a mechanism in the fixation of neo-sex chromosomes.

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