CORRELATIONAL SELECTION ON PRO- AND ANTI-INFLAMMATORY EFFECTORS
Article first published online: 26 JUN 2012
© 2012 The Author(s). Evolution© 2012 The Society for the Study of Evolution.
Volume 66, Issue 11, pages 3615–3623, November 2012
How to Cite
Guerreiro, R., Besson, A. A., Bellenger, J., Ragot, K., Lizard, G., Faivre, B. and Sorci, G. (2012), CORRELATIONAL SELECTION ON PRO- AND ANTI-INFLAMMATORY EFFECTORS. Evolution, 66: 3615–3623. doi: 10.1111/j.1558-5646.2012.01708.x
- Issue published online: 25 OCT 2012
- Article first published online: 26 JUN 2012
- Accepted manuscript online: 1 JUN 2012 02:33PM EST
- Received November 30, 2011 Accepted April 22, 2012 Data Archived: Dryad: doi:10.5061/dryad.rb89t
- Darwinian medicine;
- evolutionary immunology;
Parasites impose a permanent threat for hosts. As a consequence, immune defenses are important for host fitness. However, the immune response can also produce self-damage and impair host fitness if not properly regulated. Effectors that up- and downregulate the immune response should, therefore, evolve in concert, and be under the action of correlational selection. To address this issue, we assessed the shape of the selection operating on pro- and anti-inflammatory effectors following an inflammatory challenge in laboratory mice. We found that selection acts on the combination of these two traits as individuals that produced large amount of pro-inflammatory cytokines could achieve relatively high fitness (survival) only if also producing a large amount of anti-inflammatory effectors. To our knowledge, this is the first study providing evidence for correlational selection on immunity.