THE GENETIC ARCHITECTURE OF GROWTH RATE IN JUVENILE TAKIFUGU SPECIES
Article first published online: 17 SEP 2012
© 2012 The Author(s). Evolution© 2012 The Society for the Study of Evolution.
Volume 67, Issue 2, pages 590–598, February 2013
How to Cite
Hosoya, S., Kai, W., Fujita, M., Miyaki, K., Suetake, H., Suzuki, Y. and Kikuchi, K. (2013), THE GENETIC ARCHITECTURE OF GROWTH RATE IN JUVENILE TAKIFUGU SPECIES. Evolution, 67: 590–598. doi: 10.1111/j.1558-5646.2012.01781.x
- Issue published online: 28 JAN 2013
- Article first published online: 17 SEP 2012
- Accepted manuscript online: 24 AUG 2012 03:11AM EST
- Received May 23, 2012 Accepted August 5, 2012 Data Archived: DRYAD (doi:10.5061/dryad.18nk2)
- Body size;
- interspecific cross;
- quantitative trait locus (QTL)
Closely related species have often evolved dramatic differences in body size. Takifugu rubripes (fugu) is a large marine pufferfish whose genome has been sequenced, whereas T. niphobles is the smallest species among Takifugu. We show that, unsurprisingly, the juvenile growth rate of T. rubripes is higher than that of T. niphobles in a laboratory setting. We produced F2 progenies of their F1 hybrids and found one quantitative trait locus (QTL) significantly associated with variation in juvenile body size. This QTL region (3.5 Mb) contains no known genes directly related to growth phenotype (such as IGFs) except Fgf21, which inhibits growth hormone signaling in mouse. The QTL in Takifugu spp. is distinct from the region previously known to control body size variations in stickleback or tilapia. Our results suggest that in the fish tested herein, genomic regions underlying body size evolution might have different genetic origins. They also suggest that many diverse traits in Takifugu spp. are amenable to genetic mapping.