Students who have smoked marijuana are compared with non-users on a variety of attitudinal and demographic characteristics. Approximately 36% of the sample of over 5,000 college students from a national survey report usage of the drug. The major demographic characteristics that separate users from non-users are religious affiliation, region of the country, and sex. With respect to collegiate institutions, the selectivity of the institution, the students' academic aspirations, and grade-point average all prove to play a significant role. Anti-war activities and sentiments also prove highly significant. A Multiple Classification Analysis (MCA), which compares the relative contribution of each variable to drug usage, shows that anti-war protest, religious affiliation, and sex are the most significant predictors of marijuana usage. A variety of mechanisms playing a possible role in fostering drug use are discussed.