Requests for reprints should be sent to Dr. John W. Mason, Yale University School of Medicine, VA Medical Center/116A, West Haven, CT06516.
The Use of Psychoendocrine Strategies in Post-Traumatic Stress Disorder1
Article first published online: 31 JUL 2006
Journal of Applied Social Psychology
Volume 20, Issue 21, pages 1822–1846, December 1990
How to Cite
Mason, J. W., Kosten, T. R., Southwick, S. M. and Giller, E. L. (1990), The Use of Psychoendocrine Strategies in Post-Traumatic Stress Disorder. Journal of Applied Social Psychology, 20: 1822–1846. doi: 10.1111/j.1559-1816.1990.tb01513.x
Supported in part by Veterans Administration Research Funds and National Institute of Mental Health Research Career Award MH-00346 to J.W.M. and DA-00112 to T.R.K.
- Issue published online: 31 JUL 2006
- Article first published online: 31 JUL 2006
An overview is presented of a pilot psychoendocrine study of PTSD inpatients in comparison with several subgroups of schizophrenic and affective disorder patients. Using a hormonal profile including Cortisol, norepinephrine, epinephrine, testosterone, and thyroxine, it was found that the mean values for the PTSD group were at or near the extreme end of the range for every hormone measured, i.e., relatively low for Cortisol and high for the remaining hormones. The possible clinical meaning of these findings is considered in the light of prior psychoendocrine research on chronic stress. The hormonal alterations in PTSD appear to be persistent and suggest the possibility of being linked largely to traits or character structure, perhaps particularly to cognitive variables related to defense and coping mechanisms, as reviewed in detail for each hormonal system. There appears to be a potential for a fruitful union between the traumatic stress and psychoendocrine fields and some future strategies for developing and strengthening such a union are suggested.