Social support seems to be positively related to psychological well-being. Studies have shown that individual differences exist in the ability to mobilize and use sources of support. The current study focused on locus of control as a personality factor that might be related to this ability. In 2 samples it was shown that individuals with an internal locus of control perceived more support than did individuals with an external locus of control. Moreover, Study 1 included a sample of mainly females and showed that social support was particularly related to the psychological well-being of individuals with an external locus of control. In a second study, this moderating effect of locus of control could only be replicated for women. For men, no moderating effect of locus of control was found. The implications of these findings for interventions are discussed.