Levels of depression among rural Hispanic adolescents were assessed. Psychological factors affecting depression were examined. Included were family characteristics, measured by the Background Information Questionnaire; self-esteem, by the Piers-Harris Children's Self-Concept Scale; perceived stress level, by the Hispanic Children's Stress Inventory; acculturation, by the Cuellar Acculturation Index; and depression levels, by the Center for Epidemiological Studies-Depression Scale. Results revealed moderate to severe depression symptomatology among 33% of the subjects, and mild depression symptoms among 17%. Two family structure variables, birth order and number of brothers, were significantly related to depression. Gender was an important predictor of depression, as was self-esteem. Higher stress scores were related to higher levels of depression.