The present study examined whether employees high in negative affectivity (NA) are destined to be unhappy at work. Managerial employees provided information regarding perceptions of job characteristics, negative affectivity (NA), job satisfaction, and intentions to turnover. Using hierarchical regression, our findings suggest that employees who reported being high NA were more reactive to the environmental cues of perceived job scope. Specifically, NA interacted with job scope such that individuals high in NA who perceived their jobs as being higher (lower) in scope reported more (less) job satisfaction than did individuals low in NA. Implications for organizations and future research directions are discussed.