This study examined whether minority-status stresses and acculturative stresses increase the risk of psychological maladjustment of Latino students at a university where Latinos constitute the largest ethnic group. Participants were 338 Latino (228 Mexican American, 110 Central American) college students who responded to a mailed survey. The results of 2 separate hierarchical regression analyses of psychological distress and well-being, controlling for demographic (gender, socioeconomic status, and ethnicity). sociocultural (level of acculturation), college role (generic college stresses), and personal (academic self-confidence) influences provided partial support for our hypothesis and demonstrated the incremental predictive validity of acculturative stresses, but not of minority-status stresses. Results are discussed in terms of the variety of stresses that Latino college students are likely to experience.