In separating immigrant-specific daily hassles (out-group, family, and in-group) from immigrant-nonspecific general hassles, the relations of hassles to depression and physical symptoms were examined. The respondents were 79 female and 85 male Iranian immigrants to Canada. In Block 1 of a hierarchical multiple regression analysis, the experience of out-group hassles and of general hassles both contributed to the prediction of depression. In Block 2, psychological adjustment and perceived cultural competence in the host society, along with out-group hassles, predicted depression. General hassles were the only predictor of physical symptoms. Psychological adjustment, as a buffer, interacted with hassles in enhancing the prediction of distress. The importance of distinguishing and accounting for both immigrant-specific and immigrant-nonspecific hassles in predicting outcome measures was considered, as was the importance of assessing dispositional variables in this context.