Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to assess the structure of a coping with illness scale. Two HIV-positive samples from different geographical areas were used to verify the underlying factor structure: a sample of 320 young adults (M age = 20.9 years; 72% males) and a second sample of 273 older adults (M= 38.1 years; 81% females). Exploratory results with the young adult sample assuming correlated factors showed 7 reliable factors; CFA results supported these findings in that sample. Confirmation of the 7 derived subscales using the adult sample was found using CFA, although 2 subscale reliabilities were just below .50. Correlations between the 7 sub-scales and other scales used for construct validation were generally as predicted. Coping similarities and differences between HIV-infected young adult and adult populations are discussed.