The risk perception attitude (RPA) framework classifies people into 4 groups based on their perceptions of risk and personal efficacy: responsive (high risk, high efficacy), avoidance (high risk, low efficacy), proactive (low risk, high efficacy), and indifference (low risk, low efficacy). This study tested the central propositions from the RPA framework among a group of immigrant Indian women (N = 413) in the Washington, DC area in their propensity to pay attention to breast cancer information and engage in self-exams and clinical screening. Self-efficacy and knowledge about breast cancer were consistent predictors of these outcomes. Use of the RPA framework explained 16% to 27% of the variance. Implications for breast cancer prevention campaigns are discussed.