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The scientific impotence discounting hypothesis predicts that people resist belief-disconfirming scientific evidence by concluding that the topic of study is not amenable to scientific investigation. In 2 studies, participants read a series of brief abstracts that either confirmed or disconfirmed their existing beliefs about a stereotype associated with homosexuality. Relative to those reading belief-confirming evidence, participants reading belief-disconfirming evidence indicated more belief that the topic could not be studied scientifically and more belief that a series of other unrelated topics could not be studied scientifically. Thus, being presented with belief-disconfirming scientific evidence may lead to an erosion of belief in the efficacy of scientific methods.