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This study investigated weight stigmatization as a predictor of adjustment in samples of 100 undergraduates and 99 bariatric patients. Coping strategies (emotion-focused coping, problem-focused coping, disengagement coping) were tested as moderators of this relation. Weight stigmatization predicted depression, anxiety, and antisocial behavior when controlling for the effects of stressful life events. Problem-focused coping weakened the association between weight stigmatization and depression. Emotion-focused coping augmented the relation between weight stigmatization and antisocial behavior. The results support weight stigmatization as a meaningful predictor of adjustment difficulties. Engendering a problem-focused coping style over an emotion-focused coping style might benefit patients reporting weight stigmatization. Further work is necessary to understand what specific elements of these coping styles impact adjustment.