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The Kluyveromyces lactis repertoire of transcriptional regulators

  1. Françoise Bussereau1,
  2. Serge Casaregola2,
  3. Jean-François Lafay1,
  4. Monique Bolotin-Fukuhara1

Article first published online: 2 FEB 2006

DOI: 10.1111/j.1567-1364.2006.00028.x

Issue

FEMS Yeast Research

FEMS Yeast Research

Volume 6, Issue 3, pages 325–335, May 2006

Additional Information

How to Cite

Bussereau, F., Casaregola, S., Lafay, J.-F. and Bolotin-Fukuhara, M. (2006), The Kluyveromyces lactis repertoire of transcriptional regulators. FEMS Yeast Research, 6: 325–335. doi: 10.1111/j.1567-1364.2006.00028.x

Author Information

  1. 1

    Institut de Génétique et Microbiologie, UMR 8621 CNRS, Université Paris-Sud, Orsay, France

  2. 2

    Microbiologie et Génétique Moléculaire UMR INRA CNRS INA-PG; Thiverval-Grignon, France

*Correspondence: M. Bolotin-Fukuhara, Institut de Génétique et Microbiologie Batiment 400, Université Paris Sud 91405 Orsay Cedex France. Tel.: +33 16 915 6201; fax: +33 16 915 7296; e-mail: bolotin@igmors.u-psud.fr

  1. Editor: Lex Scheffers

Publication History

  1. Issue published online: 19 APR 2006
  2. Article first published online: 2 FEB 2006
  3. Received 12 June 2005; revised 3 August 2005; accepted 5 August 2006.First published online 2 February 2005.

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Keywords:

  • Saccharomyces cerevisiae;
  • Kluyveromyces lactis;
  • comparative genomics;
  • transcriptional regulation;
  • DNA-binding motifs

Abstract

We have exploited the recently obtained complete genome sequence of Kluyveromyces lactis to compare the repertoire of transcriptional regulators between K. lactis and Saccharomyces cerevisiae. Looking for similarities with the S. cerevisiae proteins of this functional class, we observed a reduction in gene number, which is not randomly distributed among the different DNA-binding classes, the zinc binuclear cluster class (Zn(II)2Cys6), specific to ascomycetes, being one of the most affected. However, when one examines the number of proteins that, in the K. lactis genome, possess the different DNA-binding signatures, it is not reduced compared to S. cerevisiae. This indicates that transactivator proteins have strongly diverged between the two species and cannot be recognized any more, and/or that each genome has developed a specific set of regulators to adapt the cell to its specific niches. These two aspects are discussed on the basis of available data.

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