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Structure of Kluyveromyces lactis subtelomeres: duplications and gene content

  1. Cécile Fairhead,
  2. Bernard Dujon

Article first published online: 11 JAN 2006

DOI: 10.1111/j.1567-1364.2006.00033.x

Issue

FEMS Yeast Research

FEMS Yeast Research

Volume 6, Issue 3, pages 428–441, May 2006

Additional Information

How to Cite

Fairhead, C. and Dujon, B. (2006), Structure of Kluyveromyces lactis subtelomeres: duplications and gene content. FEMS Yeast Research, 6: 428–441. doi: 10.1111/j.1567-1364.2006.00033.x

Author Information

  1. Unité de Génétique Moléculaire des Levures, Département Structure et Dynamique des Génomes, Institut Pasteur, Paris, France

*Correspondence: Cécile Fairhead, Unité de Génétique Moléculaire des Levures (URA 2171 CNRS, UFR 927 Université Pierre et Marie Curie), Département Structure et Dynamique des Génomes, Institut Pasteur, 75724 Paris Cedex, France. Tel.: +33 1 45 68 87 69; fax +33 1 40 61 34 56; e-mail: cfair@pasteur.fr

Publication History

  1. Issue published online: 19 APR 2006
  2. Article first published online: 11 JAN 2006
  3. Received 22 April 2005; revised 20 September 2005; accepted 14 October 2005.First published online 11 January 2006.

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Keywords:

  • fungal chromosome;
  • gene duplication;
  • long terminal repeats;
  • retrotransposon;
  • pseudogene;
  • subtelomere

Abstract

We have constructed a map of the duplicated regions of Kluyveromyces lactis subtelomeres. Seven out of 12 subtelomeres contain an almost identical 9 kb long segment starting from the end. This segment is bordered by a long terminal repeat element. Two of the subtelomeres share sequence similarity that extends over a total of 20 kb. The other subtelomeres also contain duplicated regions of 1–6 kb. Nonduplicated regions contain unique genes and genes from paralog families. All duplicated segments are in the same orientation with respect to the telomere, probably as a result of genetic exchange. We map the only two copies of retrotransposons in the genome, in subtelomeres. Low-complexity gene sequences that encode threonine- and serine-rich peptides are associated with the subtelomeres of K. lactis, as in Saccharomyces cerevisiae. The ubiquity of these sequences in hemiascomycete genomes, and the propensity they have to encode proteins with extracellular localization, make these genes ideal candidates for fast evolving ‘contingency’ genes involved in the adaptation of a species to its environment.

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