Editor: Ian Dawes
Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase
Article first published online: 8 JUL 2008
© 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Yeast Research
Volume 8, Issue 5, pages 676–684, August 2008
How to Cite
Gray, M., Piccirillo, S., Purnapatre, K., Schneider, B. L. and Honigberg, S. M. (2008), Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase. FEMS Yeast Research, 8: 676–684. doi: 10.1111/j.1567-1364.2008.00406.x
- Issue published online: 8 JUL 2008
- Article first published online: 8 JUL 2008
- Received 29 February 2008; revised 23 April 2008; accepted 26 May 2008.First published online July 2008.
Several components of the glucose induction pathway, namely the Snf3p glucose sensor and the Rgt1p and Mth1p transcription factors, were shown to be involved in inhibition of sporulation by glucose. The glucose sensors had only a minor role in regulating transcript levels of the two key regulators of meiotic initiation, the Ime1p transcription factor and the Ime2p kinase, but a major role in regulating Ime2p stability. Interestingly, Rgt1p was involved in glucose inhibition of spore formation but not inhibition of Ime2p stability. Thus, the glucose induction pathway may regulate meiosis through both RGT1-dependent and RGT1-independent pathways.