Present addresses: Maria José Leandro, CBAA, IJA-UTL, Tapada da Ajuda 1349-017, Lisbon, Portugal. César Fonseca, Instituto de Tecnologia Química i Biológia, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal.
Hexose and pentose transport in ascomycetous yeasts: an overview
Article first published online: 1 MAY 2009
© 2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Yeast Research
Volume 9, Issue 4, pages 511–525, June 2009
How to Cite
Leandro, M. J., Fonseca, C. and Gonçalves, P. (2009), Hexose and pentose transport in ascomycetous yeasts: an overview. FEMS Yeast Research, 9: 511–525. doi: 10.1111/j.1567-1364.2009.00509.x
Editor: André Goffeau
- Issue published online: 8 MAY 2009
- Article first published online: 1 MAY 2009
- Received 16 November 2008; revised 10 February 2009; accepted 13 February 2009.First published online May 2009.
- yeast carbon metabolism;
- yeast transporter genes;
- xylose transport;
- arabinose transport;
- fructose transport;
- sugar proton symporter
The biochemical characterization of sugar uptake in yeasts started five decades ago and led to the early production of abundant kinetic and mechanistic data. However, the first accurate overview of the underlying sugar transporter genes was obtained relatively late, due mainly to the genetic complexity of hexose uptake in the model yeast Saccharomyces cerevisiae. The genomic era generated in turn a massive amount of information, allowing the identification of a multitude of putative sugar transporter and sensor-encoding genes in yeast genomes, many of which are phylogenetically related. This review aims to briefly summarize our current knowledge on the biochemical and molecular features of the transporters of hexoses and pentoses in yeasts, when possible establishing links between previous kinetic studies and genomic data currently available. Emphasis is given to recent developments concerning the identification of d-xylose and l-arabinose transporter genes, which are thought to be key players in the optimization of S. cerevisiae strains for bioethanol production from lignocellulose hydrolysates.