Editor: David Goldfarb
Preserving organelle vitality: peroxisomal quality control mechanisms in yeast
Article first published online: 29 MAY 2009
© 2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
FEMS Yeast Research
Volume 9, Issue 6, pages 808–820, September 2009
How to Cite
Aksam, E. B., De Vries, B., Van Der Klei, I. J. and Kiel, J. A.K.W. (2009), Preserving organelle vitality: peroxisomal quality control mechanisms in yeast. FEMS Yeast Research, 9: 808–820. doi: 10.1111/j.1567-1364.2009.00534.x
- Issue published online: 7 AUG 2009
- Article first published online: 29 MAY 2009
- Received 11 February 2009; revised 1 May 2009; accepted 19 May 2009.Final version published online 16 June 2009.
- reactive oxygen species;
Cellular proteins and organelles such as peroxisomes are under continuous quality control. Upon synthesis in the cytosol, peroxisomal proteins are kept in an import-competent state by chaperones or specific proteins with an analogous function to prevent degradation by the ubiquitin–proteasome system. During protein translocation into the organelle, the peroxisomal targeting signal receptors (Pex5, Pex20) are also continuously undergoing quality control to enable efficient functioning of the translocon (RADAR pathway). Even upon maturation of peroxisomes, matrix enzymes and peroxisomal membranes remain subjected to quality control. As a result of their oxidative metabolism, peroxisomes are producers of reactive oxygen species (ROS), which may damage proteins and lipids. To counteract ROS-induced damage, yeast peroxisomes contain two important antioxidant enzymes: catalase and an organelle-specific peroxiredoxin. Additionally, a Lon-type protease has recently been identified in the peroxisomal matrix, which is capable of degrading nonfunctional proteins. Finally, cellular housekeeping processes keep track of the functioning of peroxisomes so that dysfunctional organelles can be quickly removed via selective autophagy (pexophagy). This review provides an overview of the major processes involved in quality control of yeast peroxisomes.