Yeast as a model for studying Alzheimer's disease

Authors

  • Prashant Bharadwaj,

    1. Centre of Excellence for Alzheimer's Disease Research & Care, School of Exercise, Biomedical & Health Sciences, Edith Cowan University, Perth, WA, Australia
    2. CSIRO Molecular and Health Technologies and P-Health Flagship, Parkville, Vic., Australia
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  • Ralph Martins,

    1. Centre of Excellence for Alzheimer's Disease Research & Care, School of Exercise, Biomedical & Health Sciences, Edith Cowan University, Perth, WA, Australia
    2. Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, WA, Australia
    3. School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia
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  • Ian Macreadie

    1. Centre of Excellence for Alzheimer's Disease Research & Care, School of Exercise, Biomedical & Health Sciences, Edith Cowan University, Perth, WA, Australia
    2. Sienna Cancer Diagnostics, c/- Bio21 Institute, University of Melbourne, Parkville, Vic., Australia
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  • Editor: Claude Gaillardin

Correspondence: Ian Macreadie, Sienna Cancer Diagnostics, c/- Bio21 Institute, University of Melbourne, 30 Flemington Road, Building 404, Vic. 3010, Australia. Tel.: +61 9347 0622; fax: +61 3 9347 4413; e-mail: ianm@unimelb.edu.au

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by acute cognitive decline. The AD brain is featured by extracellular senile amyloid plaques, intraneuronal neurofibrillary tangles and extensive neuronal cell loss in specific regions of the brain associated with memory. The exact mechanism of neuronal cell dysfunction leading to the memory loss in AD is poorly understood. A number of studies have indicated that yeast is a suitable model system to decipher the molecular mechanisms involved in a variety of neurodegenerative disorders caused by pathological protein misfolding and deposition. Here, the knowledge from various studies that have utilized a yeast model to study the mechanism of pathways involved in AD pathogenesis is summarized.

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