Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast


Correspondence: Tomasz Biliński, Department of Biochemistry and Cell Biology, University of Rzeszów, Zelwerowicza 4, 35-601 Rzeszów, Poland. Tel.: +48 17 7855406; fax: +48 17 8721265; e-mail:


This paper summarizes numerous arguments demonstrating that the hypothesis of accumulation of the senescence factor, which was the basis for introducing yeast to the group of model organisms of gerontology, finds no experimental support. Among several candidates for the role of the causative agents of replicative aging, only one – hypertrophy – always accompanies symptoms of aging, not only in Saccharomyces cerevisiae, but also in Schizosaccharomyces pombe.