Editor: Willem van Leeuwen
SCCmec in staphylococci: genes on the move
Article first published online: 19 SEP 2005
FEMS Immunology & Medical Microbiology
Volume 46, Issue 1, pages 8–20, February 2006
How to Cite
Hanssen, A.-M. and Ericson Sollid, J. U. (2006), SCCmec in staphylococci: genes on the move. FEMS Immunology & Medical Microbiology, 46: 8–20. doi: 10.1111/j.1574-695X.2005.00009.x
- Issue published online: 19 SEP 2005
- Article first published online: 19 SEP 2005
- Received 21 April 2005; revised 17 June 2005; accepted 22 July 2005.
- cassette chromosome recombinase;
- coagulase-negative staphylococci;
- horizontal gene transfer;
- methicillin-resistant Staphylococcus aureus;
Staphylococcal cassette chromosome (SCC) elements are, so far, the only vectors described for the mecA gene encoding methicillin resistance in staphylococci. SCCmec elements are classified according to the type of recombinase they carry and their general genetic composition. SCCmec types I–V have been described, and SCC elements lacking mecA have also been reported. In this review, we summarize the current knowledge about SCC structure and distribution, including genetic variants and rudiments of the elements. Its origin is still unknown, but one assumes that staphylococcal cassette chromosome is transferred between staphylococci, and mecA-positive coagulase-negative staphylococci may be a potential reservoir for these elements. Staphylococcal genomes seem to change continuously as genetic elements move in and out, but no mechanism of transfer has been found responsible for moving SCC elements between different staphylococcal species. Observations suggesting de novo production of methicillin-resistant staphylococci and horizontal gene transfer of SCCmec will be discussed.