Editor: Johannes Kusters
Changes of immunoresponse in BALB/c mice neonatally treated with periodontopathic bacterial endotoxin
Article first published online: 26 MAY 2006
FEMS Immunology & Medical Microbiology
Volume 47, Issue 3, pages 420–424, August 2006
How to Cite
Kato, T., Kimizuka, R. and Okuda, K. (2006), Changes of immunoresponse in BALB/c mice neonatally treated with periodontopathic bacterial endotoxin. FEMS Immunology & Medical Microbiology, 47: 420–424. doi: 10.1111/j.1574-695X.2006.00106.x
- Issue published online: 26 MAY 2006
- Article first published online: 26 MAY 2006
- Received 27 January 2006; revised 6 March 2006; accepted 31 March 2006.First published online 26 May 2006.
- animal models;
- periodontopathic bacteria;
The aim of this investigation was to analyze the effects of early life exposure to periodontopathic bacterial lipopolysaccharides on immunoresponse. Newborn BALB/c mice were subcutaneously injected with 20 ng lipopolysaccharide of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans or Escherichia coli daily for 2 days, starting within 24 h after birth. The treated mice were given intraperitoneal injections of bovine serum albumin at 180 and 187 days of age. Seventeen hours after each injection, the mice were bled and sera were separated. Their sera were tested in an enzyme-linked immunosorbent assay system. The mean interleukin-4, interleukin-5, interleukin-6 and immunoglobulin E levels in the sera of mice treated neonatally with P. gingivalis lipopolysaccharide were significantly higher than those of the controls. However, in all cases, no significant difference was noted between mice treated neonatally with A. actinomycetemcomitans- or E. coli lipopolysaccharide and control mice. These data suggest that neonatal exposure to P. gingivalis lipopolysaccharide induces changes in immunological responses when the mice reach maturity.