Editor: Alex van Belkum
Effect of salicylic acid on invasion of human vascular endothelial cells by Staphylococcus aureus
Article first published online: 9 NOV 2006
FEMS Immunology & Medical Microbiology
Volume 49, Issue 1, pages 56–61, February 2007
How to Cite
Park, W. B., Kim, S.-H., Cho, J. H., Bang, J. H., Kim, H. B., Kim, N. J., Oh, M.-d. and Choe, K. W. (2007), Effect of salicylic acid on invasion of human vascular endothelial cells by Staphylococcus aureus. FEMS Immunology & Medical Microbiology, 49: 56–61. doi: 10.1111/j.1574-695X.2006.00170.x
- Issue published online: 24 JAN 2007
- Article first published online: 9 NOV 2006
- Received 23 August 2006; accepted 27 September 2006.First published online 9 November 2006.
- staphylococcus aureus;
- endothelial cells;
- salicylic acid
Invasion of vascular endothelial cells by Staphylococcus aureus is associated with diverse complications and recurrent infection. Little is known about the effect of salicylic acid, the major metabolite of aspirin, on the interaction between S. aureus and vascular endothelial cells. We examined the adhesion of S. aureus strain 8325-4 cultured with or without salicylic acid to human umbilical vein endothelial cells (HUVECs), and the ability of the strain to invade these cells. Strain 8325-4 cells grown in salicylic acid were significantly less adherent to and invasive in HUVECs. Production of cytokine interleukin (IL)-6 was lower from the HUVECs infected with clinical isolates of S. aureus cultured in salicylic acid compared with those unexposed to salicylic acid. This study raises the possibility of using salicylic acid as an adjuvant therapeutic agent in the treatment of S. aureus bacteremia to prevent its complications or recurrence.