Editor: Patrick Brennan
Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses
Article first published online: 21 DEC 2006
FEMS Immunology & Medical Microbiology
Volume 49, Issue 1, pages 68–74, February 2007
How to Cite
Zhang, M., Yang, Y., Xu, Y., Qie, Y., Wang, J., Zhu, B., Wang, Q., Jin, R., Xu, S. and Wang, H. (2007), Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses. FEMS Immunology & Medical Microbiology, 49: 68–74. doi: 10.1111/j.1574-695X.2006.00174.x
- Issue published online: 24 JAN 2007
- Article first published online: 21 DEC 2006
- Received 23 March 2006; revised 18 September 2006; accepted 4 October 2006.First published online 21 December 2006.
- Mycobacterium tuberculosis;
- bacillus Calmette-Guérin (BCG);
- trehalose-6-phosphate phosphatase
Trehalose-6-phosphate phosphatase is an enzyme strictly essential for the growth of mycobacteria. Subcellular fractionation of Mycobacterium tuberculosis and M. bovis bacillus Calmette-Guérin (BCG) located the trehalose-6-phosphate phosphatase in the cell wall and membrane fractions. Trehalose-6-phosphate phosphatase induced an increased Th1-type immune response in mice, characterized by an elevated level of interferon-γ in antigen-stimulated splenocyte culture and a strong IgG2a antibody response. The trehalose-6-phosphate phosphatase was recognized by the sera of tuberculosis patients and BCG-vaccinated donors. The mycobacterial trehalose-6-phosphate phosphatase is an immunodominant antigen, and it may be a candidate for vaccine development for the control of tuberculosis.