Editor: Willem van Eden
Primary and secondary immune responses of mucosal and peripheral lymphocytes during Chlamydia trachomatis infection
Article first published online: 25 JAN 2007
FEMS Immunology & Medical Microbiology
Volume 49, Issue 2, pages 280–287, March 2007
How to Cite
Vats, V., Agrawal, T., Salhan, S. and Mittal, A. (2007), Primary and secondary immune responses of mucosal and peripheral lymphocytes during Chlamydia trachomatis infection. FEMS Immunology & Medical Microbiology, 49: 280–287. doi: 10.1111/j.1574-695X.2006.00196.x
- Issue published online: 25 JAN 2007
- Article first published online: 25 JAN 2007
- Received 22 August 2006; revised 11 October 2006; accepted 6 November 2006.First published online 25 January 2007.
- proliferative response;
- MOMP antigen;
- Chlamydia trachomatis
Chlamydia trachomatis infection is followed by the development of antigen-specific cell-mediated immunity, which is detectable as a positive lymphocyte proliferation response to the chlamydial major outer membrane protein (MOMP) antigen. To date, however, there have been no studies on the mucosal immune responses to chlamydial antigens. This study aimed to study the primary and secondary immune responses of cervical lymphocytes in response to the chlamydial antigen. Median proliferative responses were found to be significantly (P<0.05) higher in patients with chlamydial infections than in controls. The chlamydial MOMP induced significantly higher IL-6 and IL-10 and lower interferon-gamma (IFN-γ) secretion in cervical lymphocytes of Chlamydia-positive women, resulting in a T helper 2 response. On stimulation of peripheral blood mononuclear cells (PBMC) obtained from Chlamydia-positive women with the chlamydial antigen, the median levels of IL-10, IL-12 and IFN-γ were higher than in controls, but the differences were not significant. Our study suggests that the mucosal immune responses towards Chlamydia trachomatis are different from those of PBMCs and are more helpful in understanding the cytokine responses in the female genital tract during chlamydial infection.