Editor: Willem van Eden
Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response
Version of Record online: 28 MAR 2007
FEMS Immunology & Medical Microbiology
Volume 50, Issue 1, pages 59–66, June 2007
How to Cite
Mascolo, D., Barba, P., De Berardinis, P., Di Rosa, F. and Del Pozzo, G. (2007), Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response. FEMS Immunology & Medical Microbiology, 50: 59–66. doi: 10.1111/j.1574-695X.2007.00229.x
- Issue online: 28 MAR 2007
- Version of Record online: 28 MAR 2007
- Received 20 September 2006; revised 18 December 2006; accepted 23 January 2007.First published online 28 March 2007.
- multiepitopic carrier
The Ovalbumin257–264 CTL epitope on the major coat protein of the filamentous bacteriophage in different antigen formulations was displayed and the immune response in C57BL6/J mice studied. The display of single cytotoxic epitope on the surface of the virion is sufficient to induce priming and sustain long-term major histocompatibility complex class I restricted cytotoxic T lymphocytes response in vivo. The filamentous bacteriophage is a versatile carrier able to display simultaneously either single or multiple epitopes and can elicit a cellular response carrying very little peptide (<1.5 μg).