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References

  • Asmuth DM, Olson RD, Hackett SP, Bryant AE, Tweten RK, Tso JY, Zollman T & Stevens DL (1995) Effects of Clostridium perfringens recombinant and crude phospholipase C and theta-toxin on rabbit hemodynamic parameters. J Infect Dis 172: 13171323.
  • Awad MM, Bryant AE, Stevens DL & Rood JI (1995) Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene. Mol Microbiol 15: 191202.
  • Bryant AE & Stevens DL (1996) Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cell-leukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells. Infect Immun 64: 358362.
  • Bryant AE & Stevens DL (1997) The pathogenesis of gas gangrene. The Clostridia: Molecular Biology and Pathogenesis (RoodJI, McClaneBA, SongerJG & TitballRW, eds), pp. 185196. Academic Press, San Diego, CA.
  • Bryant AE, Chen RY, Nagata Y, Wang Y, Lee CH, Finegold S, Guth PH & Stevens DL (2000a) Clostridial gas gangrene. II. Phospholipase C-induced activation of platelet gpIIbIIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene. J Infect Dis 182: 808815.
  • Bryant AE, Chen RY, Nagata Y, Wang Y, Lee CH, Finegold S, Guth PH & Stevens DL (2000b) Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens. J Infect Dis 182: 799807.
  • Bryant AE, Bayer CR, Aldape MJ, Wallace RJ, Titball RW & Stevens DL (2006) Clostridium perfringens phospholipase C-induced platelet/leukocyte interactions impede neutrophil diapedesis. J Med Microbiol 55: 495504.
  • Buiting AM & Van Rooijen N (1994) Liposome mediated depletion of macrophages: an approach for fundamental studies. J Drug Target 2: 357362.
  • Bunting M, Lorant DE, Bryant AE, Zimmerman GA, McIntyre TM, Stevens DL & Prescott SM (1997) Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. J Clin Invest 100: 565574.
  • Lyristis M, Bryant AE, Sloan J, Awad MM, Nisbet IT, Stevens DL & Rood JI (1994) Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens. Mol Microbiol 12: 761777.
  • Melville SB, Labbe R & Sonenshein AL (1994) Expression from the Clostridium perfringenscpe promoter in C. perfringens and Bacillus subtilis. Infect Immun 62: 55505558.
  • O'Brien DK & Melville SB (2000) The anaerobic pathogen Clostridium perfringens can escape the phagosome of macrophages under aerobic conditions. Cellular Microbiol 2: 505519.
  • O'Brien DK & Melville SB (2003) Multiple effects on Clostridium perfringens binding, uptake and trafficking to lysosomes by inhibitors of macrophage phagocytosis receptors. Microbiology 149: 13771386.
  • O'Brien DK & Melville SB (2004) Effects of Clostridium perfringens alpha toxin (PLC) and perfringolysin O (PFO) on cytotoxicity towards macrophages, escape from the phagosome of macrophages and persistence of C. perfringens in host tissues. Infect Immun 72: 52045215.
  • Present DA, Meislin R & Shaffer B (1990) Gas gangrene. A review. Orthop Rev 19: 333341.
  • Qian Q, Jutila MA, Van Rooijen N & Cutler JE (1994) Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J Immunol 152: 50005008.
  • Rogers HW & Unanue ER (1993) Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect Immun 61: 50905096.
  • Rood JI (1998) Virulence genes of Clostridium perfringens. Annu Rev Microbiol 52: 333360.
  • Rood JI & Cole ST (1991) Molecular genetics and pathogenesis of Clostridium perfringens. Microbiol Rev 55: 621648.
  • Spitznagel JK (1984) Nonoxidative antimicrobial reactions of leukocytes. Contemp Top Immunobiol 14: 283343.
  • Stevens DL (1997) Necrotizing clostridial soft tissue infections. The Clostridia: Molecular Biology and Pathogenesis (RoodJI, McClaneBA, SongerJG & TitballRW, eds), pp. 141152. Academic Press, San Diego, CA.
  • Stevens DL (2000) The pathogenesis of clostridial myonecrosis. Int J Med Microbiol 290: 497502.
  • Stevens DL & Bryant AE (1993) Role of theta toxin, a sulfhydryl-activated cytolysin, in the pathogenesis of clostridial gas gangrene. Clin Infect Dis 16: S195S199.
  • Stevens DL & Bryant AE (2002) The role of clostridial toxins in the pathogenesis of gas gangrene. Clin Infect Dis 35: S93S100.
  • Stevens DL, Mitten J & Henry C (1987) Effects of alpha and theta toxins from Clostridium perfringens on human polymorphonuclear leukocytes. J Infect Dis 156: 324333.
  • Stevens DL, Troyer BE, Merrick DT, Mitten JE & Olson RD (1988) Lethal effects and cardiovascular effects of purified alpha- and theta-toxins from Clostridium perfringens. J Infect Dis 157: 272279.
  • Stevens DL, Tweten RK, Awad MM, Rood JI & Bryant AE (1997) Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J Infect Dis 176: 189195.
  • Van Rooijen N & Sanders A (1994) Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods 174: 8393.