Present address: Courtney Shires, Department of Otolaryngology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Characterization of Streptococcus pneumoniae isolated from children with otitis media
Article first published online: 23 APR 2007
FEMS Immunology & Medical Microbiology
Volume 50, Issue 1, pages 119–125, June 2007
How to Cite
Onwubiko, C., Shires, C., Quin, L. R., Swiatlo, E. and McDaniel, L. S. (2007), Characterization of Streptococcus pneumoniae isolated from children with otitis media. FEMS Immunology & Medical Microbiology, 50: 119–125. doi: 10.1111/j.1574-695X.2007.00245.x
Editor: Jenelle Kyd
- Issue published online: 23 APR 2007
- Article first published online: 23 APR 2007
- Received 28 December 2006; accepted 23 February 2007.First published online April 2007.
- otitis media;
- capsular serotypes;
- BOX PCR
Streptococcus pneumoniae is the main causative agent of acute otitis media in children. Serotype-based vaccines have provided some protection against otitis media, but not as much as anticipated, demonstrating the need for alternative vaccine options. Pneumococcal otitis media isolates were obtained from children 5 years old or younger from hospitals around Mississippi in the prevaccine era (1999–2000). These isolates were compared by capsular typing, pneumococcal surface protein A (PspA) family typing, antibiotic susceptibility, and DNA fingerprinting. Our study shows that there is great genetic variability among pneumococcal clinical isolates of otitis media, except with regard to PspA. Therefore, efforts focused on the development of a PspA-based pneumococcal vaccine would be well placed.