Editor: Patrick Brennan
Coxiella burnetii infection in C57BL/6 mice aged 1 or 14 months
Article first published online: 7 JUN 2007
FEMS Immunology & Medical Microbiology
Volume 50, Issue 3, pages 396–400, August 2007
How to Cite
Leone, M., Bechah, Y., Meghari, S., Lepidi, H., Capo, C., Raoult, D. and Mege, J.-L. (2007), Coxiella burnetii infection in C57BL/6 mice aged 1 or 14 months. FEMS Immunology & Medical Microbiology, 50: 396–400. doi: 10.1111/j.1574-695X.2007.00272.x
- Issue published online: 7 JUN 2007
- Article first published online: 7 JUN 2007
- Received 22 October 2006; revised 26 March 2007; accepted 2 April 2007.First published online 7 June 2007.
- Coxiella burnetii;
The objective of this study was to investigate the effects of age on infection with Coxiella burnetii, the agent of Q fever. Bacterial burden and granuloma number were increased in the spleens of 14-month-old as compared with 1-month-old mice. This increase was not the result of an anti-inflammatory macrophage response, because inflammatory and anti-inflammatory cytokines were induced in macrophages from young mice but were repressed in mature mice. In addition, macrophage microbicidal competence was similar in mature and young mice. These results suggest the importance of individual host factors in the pathophysiology of an infectious disease such as Q fever.