Osteomyelitis and the role of biofilms in chronic infection


  • Editor: Willem van Leeuwen

Correspondence: Mark E. Shirtliff, Department of Biomedical Sciences, Dental School, University of Maryland-Baltimore, 650 W. Baltimore Street, Rm 9209, Baltimore, MD 21201, USA. Tel.: +410 706 2263; fax: +410 706 0865; e-mail: mshirtliff@umaryland.edu


Understanding the mechanisms implicated in the initial attachment, development, and maturation of a biofilm phenotype are of tremendous importance for their effect on the medical, industrial, and public health arenas. This review explores the current understanding of the nature of biofilms and the impact that molecular interactions between the bacteria themselves, as well as between bacteria and the host, may have on biofilm development and phenotype using the nonmotile Gram-positive coccus, Staphylococcus aureus, as an example.