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Osteomyelitis and the role of biofilms in chronic infection

  1. Rebecca A. Brady1,
  2. Jeff G. Leid2,
  3. Jason H. Calhoun3,
  4. J. William Costerton4,
  5. Mark E. Shirtliff1,5

Article first published online: 13 DEC 2007

DOI: 10.1111/j.1574-695X.2007.00357.x

Issue

FEMS Immunology & Medical Microbiology

FEMS Immunology & Medical Microbiology

Volume 52, Issue 1, pages 13–22, January 2008

Additional Information

How to Cite

Brady, R. A., Leid, J. G., Calhoun, J. H., Costerton, J. W. and Shirtliff, M. E. (2008), Osteomyelitis and the role of biofilms in chronic infection. FEMS Immunology & Medical Microbiology, 52: 13–22. doi: 10.1111/j.1574-695X.2007.00357.x

Author Information

  1. 1

    Department of Microbiology and Immunology, University of Maryland – Baltimore, School of Medicine, Baltimore, MD, USA

  2. 2

    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA

  3. 3

    Department of Orthopaedic Surgery, University of Missouri – Columbia, Columbia, MO, USA

  4. 4

    Center for Biofilms, School of Dentistry University of Southern California, Los Angeles, CA, USA

  5. 5

    Department of Biomedical Sciences, University of Maryland – Baltimore, Dental School, Baltimore, MD, USA

*Correspondence: Mark E. Shirtliff, Department of Biomedical Sciences, Dental School, University of Maryland-Baltimore, 650 W. Baltimore Street, Rm 9209, Baltimore, MD 21201, USA. Tel.: +410 706 2263; fax: +410 706 0865; e-mail: mshirtliff@umaryland.edu

  1. Editor: Willem van Leeuwen

Publication History

  1. Issue published online: 13 DEC 2007
  2. Article first published online: 13 DEC 2007
  3. Received 2 July 2007; revised 28 September 2007; accepted 30 September 2007.First published online 13 December 2007.

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Keywords:

  • osteomyelitis;
  • biofilm;
  • Staphylococcus aureus

Abstract

Understanding the mechanisms implicated in the initial attachment, development, and maturation of a biofilm phenotype are of tremendous importance for their effect on the medical, industrial, and public health arenas. This review explores the current understanding of the nature of biofilms and the impact that molecular interactions between the bacteria themselves, as well as between bacteria and the host, may have on biofilm development and phenotype using the nonmotile Gram-positive coccus, Staphylococcus aureus, as an example.

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