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Keywords:

  • Chlamydia;
  • disease pathogenesis;
  • immunobiology;
  • arrested immunity

Abstract

Chlamydia disease expression is the result of complex molecular and cellular interactions between the host and a pathogen which appears to have been sculpted by evolutionary forces. Recent genomic, immunologic, and epidemiologic findings are reviewed. A synthesis is offered which suggests that Chlamydia disease expression results from persistent infection and host immune responses.