Prevention and control of biofilm-based medical-device-related infections


  • Editor: John Costerton

Correspondence: Gianfranco Donelli, Department of Technologies and Health, Istituto Superiore di Sanità, Viale Regina Elena, 299-00161 Rome, Italy. Tel.: +39 06 4990 2228; fax: +39 06 4938 7141; e-mail: or


Biofilms play a pivotal role in healthcare-associated infections, especially those related to the implant of medical devices, such as intravascular catheters, urinary catheters and orthopaedic implants. This paper reviews the most successful approaches for the control and prevention of these infections as well as promising perspectives for the development of novel devices refractory to microbial adhesion, colonization and biofilm formation.