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Keywords:

  • 3,4-dihydroxyphenylacetate meta-cleavage pathway;
  • catabolism;
  • phenylalanine;
  • tyrosine;
  • Brevibacterium linens

Abstract The quantitative importance of the 3,4-dihydroxyphenylacetate meta-cleavage pathway (the principal pathway of tyrosine catabolism) in the catabolism of l-phenylalanine in Brevibacterium linens 47 was evaluated using tyrosine-negative mutants. Less than 5% of phenylalanine was catabolised through the tyrosine pathway. The results presented show that in B. linens the two structurally analogous amino acids are catabolised principally by separate pathways. Also, the initial pathway of phenylalanine catabolism in this bacterium has been established.