Positive and negative regulators of the Saccharomyces cerevisiae‘PHO system’ participate in several cell functions

Authors

  • Véronique Gilliquet,

    1. Unité de Microbiologie, Faculté des Sciences agronomiques, Gembloux, Belgium
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    • 1

      Present address: Institut Provincial d'Enseignement Supérieur Pédagogique et Agricole, Rue Beeckman 19, B-4000 Liège, Belgium.

  • Gilbert Berben

    Corresponding author
    1. Unité de Microbiologie, Faculté des Sciences agronomiques, Gembloux, Belgium
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G. Berben. Present address: Station de Chimie et de Physique agricoles, Centre de Recherches agronomiques de l'Etat, 115 Chaussée de Wavre, B-5030 Gembloux, Belgium.

Abstract

Abstract The yeast PHO regulatory genes are indispensable for the transcriptional control of structural genes involved in phosphate metabolism. Some of the regulatory genes have pleiotropic functions apparently independent of phosphate metabolism. Our results point to an involvement in the life cycle of the PHO2 activator and the PHO85-negative factor and to a reduced ability of the negative pho regulatory mutants, pho80 and pho85, to grow on non-fermentable carbon sources.

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