The adenylate cyclase catalytic domain of Streptomyces coelicolor is carboxy-terminal

  1. Antoine Danchin1,
  2. Josette Pidoux2,
  3. Evelyne Krin1,
  4. Charles J. Thompson3,†,
  5. Agnes Ullmann2,*

Article first published online: 17 JAN 2006

DOI: 10.1111/j.1574-6968.1993.tb06565.x

Issue

FEMS Microbiology Letters

FEMS Microbiology Letters

Volume 114, Issue 2, pages 145–151, December 1993

Additional Information

How to Cite

Danchin, A., Pidoux, J., Krin, E., Thompson, C. J. and Ullmann, A. (1993), The adenylate cyclase catalytic domain of Streptomyces coelicolor is carboxy-terminal. FEMS Microbiology Letters, 114: 145–151. doi: 10.1111/j.1574-6968.1993.tb06565.x

Author Information

  1. 1

    Unité de Régulation de l'Expression Génétique Institut Pasteur, 75724 Paris Cedex 15, France

  2. 2

    Unité de Biochimie des Régulations Cellulaires, Institut Pasteur, 75724 Paris Cedex 15, France

  3. 3

    Unité de Génie Microbiologique, Institut Pasteur, 75724 Paris Cedex 15, France

  1. †

    Present address: Biozentrum der Universität Basel, 70 Klingelbergstrasse, CH-4056 Basel, Switzerland.

* *Corresponding author. Tel: (1) 45 68 83 85; Fax: (1) 40 61 30 19.

Publication History

  1. Issue published online: 17 JAN 2006
  2. Article first published online: 17 JAN 2006
  3. (Received 7 September 1993, Accepted 13 September 1993)

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Keywords:

  • Cyclic AMP;
  • cya Gene;
  • Sequence comparison;
  • Streptomyces coelicolor

Abstract A DNA fragment of Streptomyces coelicolor encoding the carboxy-terminal catalytic domain of adenylate cyclase was cloned, sequenced and expressed in an Escherichia colicya-defective strain where it produced nanomole levels of cAMP. The amino acid sequence of the enzyme displays similarities with the Brevibacterium liquefaciens pyruvate regulated adenylate cyclase.

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