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Codon usage in Actinobacillus actinomycetemcomitans
Article first published online: 17 JAN 2006
DOI: 10.1111/j.1574-6968.1998.tb13022.x
1574-6968/asset/cover.gif?v=1&s=069bb2c224e243333d4486580fbd90d9ebeffa6b "FEMS Microbiology Letters")
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How to Cite
Kaplan, J. B. and Fine, D. H. (1998), Codon usage in Actinobacillus actinomycetemcomitans. FEMS Microbiology Letters, 163: 31–36. doi: 10.1111/j.1574-6968.1998.tb13022.x
Publication History
- Issue published online: 17 JAN 2006
- Article first published online: 17 JAN 2006
- Received 1 December 1997, Revised 24 March 1998, Accepted 27 March 1998
- Abstract
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Keywords:
- Actinobacillus actinomycetemcomitans;
- Codon usage;
- Molecular evolution;
- G+C content;
- Horizontal gene transfer;
- Leukotoxin;
- RTX toxin;
- Plasmid
Abstract
The codon usage patterns of 21 genes encompassing 5800 codons from Actinobacillus actinomycetemcomitans were analyzed. A. actinomycetemcomitans genes could be divided into two groups based on their function and G+C content. One group included those genes encoding basic cellular functions. This group displayed an average G+C content of 48%. A second group comprised genes encoding the leukotoxin determinant, an insertion sequence and a plasmid. This group displayed an average G+C content of 36%. These findings suggest that portions of the A. actinomycetemcomitans genome may have been acquired by horizontal gene transfer from one or more distantly related species. We present a table of A. actinomycetemcomitans codon usage. These data may be used to establish standards for computer programs that predict A. actinomycetemcomitans protein coding regions and may be useful in designing degenerate oligonucleotide probes.