- Top of page
- 2Why a nuclease?
- 3An overview of the enzyme
- 4A family of nucleases
- 5Processing of the nuclease precursor
- 6Structure of nuclease
- 7Catalytic mechanism
- 8Control of nuclease expression
- 9Extracellular secretion of nuclease
- 10Nuclease and its many uses
Serratia marcescens produces an endonuclease with extraordinarily high specific activity that is released into the surrounding medium. This enzyme has been the focus of studies on gene regulation, protein secretion, endonuclease action, and protein structure; it has also been found to have many applications in biotechnology. Here we briefly review these different facets of research regarding the Serratia nuclease and summarize the current state of knowledge about this enzyme.