Herz- und Diabeteszentrim NRW, 32 545 Bad Oeynhausen, Germany.
Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli
Article first published online: 17 JAN 2006
FEMS Microbiology Letters
Volume 166, Issue 2, pages 305–309, September 1998
How to Cite
Mcmurry, L. M., Oethinger, M. and Levy, S. B. (1998), Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli. FEMS Microbiology Letters, 166: 305–309. doi: 10.1111/j.1574-6968.1998.tb13905.x
- Issue published online: 17 JAN 2006
- Article first published online: 17 JAN 2006
- Received 20 July 1998, Accepted 23 July 1998
- Multidrug efflux pump
Triclosan (Irgasan) is a broad spectrum antimicrobial agent used in handsoaps, toothpastes, fabrics, and plastics. It inhibits lipid biosynthesis in Escherichia coli, probably by action upon enoyl reductase (FabI) (McMurry L.M., Oethinger M. and Levy S.B. (1988) Nature 394, 531–532). We report here that overexpression of the multidrug efflux pump locus acrAB, or of marA or soxS, both encoding positive regulators of acrAB, decreased susceptibility to triclosan 2-fold. Deletion of the acrAB locus increased the susceptibility to triclosan approximately 10-fold. Four of five clinical E. coli strains which overexpressed marA or soxS also showed enhanced triclosan resistance. The acrAB locus was involved in the effects of triclosan upon both cell growth rate and cell lysis.