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Genetic rearrangements in the tyrB-uvrA region of the enterobacterial chromosome: a potential cause for different class B acid phosphatase regulation in Salmonella enterica and Escherichia coli

  1. Maria Cristina Thaller1,2,*,
  2. Serena Schippa2,
  3. Alessandra Bonci3,
  4. Francesca Berlutti2,
  5. Laura Selan2,
  6. Gian Maria Rossolini3

Article first published online: 17 JAN 2006

DOI: 10.1111/j.1574-6968.1999.tb08821.x

Issue

FEMS Microbiology Letters

FEMS Microbiology Letters

Volume 181, Issue 1, pages 17–23, December 1999

Additional Information

How to Cite

Thaller, M. C., Schippa, S., Bonci, A., Berlutti, F., Selan, L. and Rossolini, G. M. (1999), Genetic rearrangements in the tyrB-uvrA region of the enterobacterial chromosome: a potential cause for different class B acid phosphatase regulation in Salmonella enterica and Escherichia coli. FEMS Microbiology Letters, 181: 17–23. doi: 10.1111/j.1574-6968.1999.tb08821.x

Author Information

  1. 1

    Dipartimento di Biologia, II Università di Roma ‘Tor Vergata’, 00133 Rome, Italy

  2. 2

    Istituto di Microbiologia, Università di Roma ‘La Sapienza’, 00185 Rome, Italy

  3. 3

    Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, 53100 Siena, Italy

* *Corresponding author. Tel.: +39 (6) 445 1324; Fax: +39 (6) 4991 4638, E-mail address: pezzi@axrma.uniroma1.it

Publication History

  1. Issue published online: 17 JAN 2006
  2. Article first published online: 17 JAN 2006
  3. Received 13 September 1999, Accepted 20 September 1999

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Keywords:

  • Salmonella enterica;
  • Acid phosphatase;
  • Regulation;
  • Enterobacterial chromosome;
  • Genetic rearrangement

Abstract

Unlike in Escherichia coli, in Salmonella enterica production of class B acid phosphatase (AphA) was detectable also in cells growing in the presence of glucose. Characterization of the aphA locus from a S. enterica ser. typhi strain showed that the aphA determinant is very similar to the E. coli homolog, and that its chromosomal location between the highly conserved tyrB and uvrA genes is retained. However, the aphA flanking regions were found to be markedly different in the two species, either between tyrB and aphA or between aphA and uvrA. The differences in the aphA 5′-flanking region, which in S. enterica is considerably shorter than in E. coli (183 vs. 1121 bp) and includes potential promoter sequences not present in E. coli, could be responsible for the different regulation of class B acid phosphatase observed in the two species.

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