• 1
    Henkel, T., Rohr, J., Beale, J.M. and Schwenen, L. (1990) Landomycins. New angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins A–D. J. Antibiot. 43, 492503.
  • 2
    Depenbrock, H., Bornschlegl, S., Peter, R., Rohr, J., Schmid, P., Schweighart, P., Block, T., Rastetter, J. and Hanauske, A.-R. (1996) Assessment of antitumor activity of landomycin A (NSC 6399187-A). Ann. Hematol. 73 (Suppl. II), A80/316.
  • 3
    Decker, H. and Haag, S. (1995) Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation. J. Bacteriol. 177, 61266136.
  • 4
    Han, L., Yang, K., Ramalingam, E., Mosher, R.H. and Vining, L.C. (1994) Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230. Microbiology 140, 33793389.
  • 5
    Yang, K., Han, L., Ayer, S.W. and Vining, L.C. (1996) Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae. Microbiology 142, 123132.
  • 6
    McDaniel, R., Ebert-Khosla, S., Hopwood, D.A. and Khosla, C. (1993) Engineered biosynthesis of novel polyketides. Science 262, 15461550.
  • 7
    McDaniel, R., Ebert-Khosla, S., Hopwood, D.A. and Khosla, C. (1995) Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits. Nature 375, 549554.
  • 8
    Hutchinson, C.R. and Fujii, I. (1995) Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics. Annu. Rev. Microbiol. 49, 201238.
  • 9
    Motamedi, H., Shafiee, A., Cai, S.-J., Streicher, S.L., Arison, B.H. and Miller, R.R. (1996) Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of immunosuppressants FK506 and FK520. J. Bacteriol. 178, 52435248.
  • 10
    Hopwood, D.A., Bibb, M.J., Chater, K.F., Kieser, T., Bruton, C.J., Kieser, H.M., Lydiate, D.J., Smith, C.P., Ward, J.M. and Schrempf, H. (1985) Genetic Manipulation of Streptomyces– A Laboratory Manual. The John Innes Foundation, Norwich.
  • 11
    Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
  • 12
    Bechthold, A., Sohng, J.K., Smith, T.M., Chu, X. and Floss, H.G. (1995) Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin. Mol. Gen. Genet. 248, 610620.
  • 13
    Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman, D.J. (1990) Basic alignment search tool. J. Mol. Biol. 215, 403410.
  • 14
    Devereux, J., Haeberli, P. and Smithies, O. (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 15, 387395.
  • 15
    Decker, H., Gaisser, S., Pelzer, S., Schneider, P., Westrich, L., Wohlleben, W. and Bechthold, A. (1996) A general approach for cloning and characterizing dNDP-glucose dehydratase genes from actinomycetes. FEMS Microbiol. Lett. 141, 195201.
  • 16
    Yang, K., Han, L. and Vining, L.C. (1995) Regulation of jadomycin production in Streptomyces venezuelae ISP5230: Involvement of a repressor gene, jadR2. J. Bacteriol. 177, 61116117.
  • 17
    Huder, J.B. and Dimroth, P. (1993) Sequence of the sodium ion pump methylmalonyl-CoA decarboxylase from Veillonella parvula. J. Biol. Chem. 268, 2456424571.
  • 18
    Summers, R.G., Wendt-Pienkowski, E., Motamedi, H. and Hurchinson, C.R. (1993). The tcmVI region of the tetracenomycin C biosynthesis gene cluster of Streptomyces glaucescens encodes the teracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase. J. Bacteriol. 175, 7571–7580.
  • 19
    Hopwood, D.A. (1997) Genetic contributions to understanding polyketide synthases. Chem. Rev. 97, 24662497.
  • 20
    Piepersberg, W. (1994) Pathway engineering in secondary metabolite-producing actinomycetes. Crit. Rev. Biotechnol. 14, 251285.
  • 21
    Thorson, J.S., Lo, S.F. and Liu, H.-w. (1993) Molecular basis of 3,6-dideoxyhexose biosynthesis: elucidation of CDP-ascarylose biosynthetic genes and their relationship to other 3,6-dideoxyhexose pathways. J. Am. Chem. Soc. 115, 58275828.
  • 22
    Scotti, C. and Hutchinson, C.R. (1996) Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis. J. Bacteriol. 178, 73167321.
  • 23
    Niemi, J. and Mäntsälä, P. (1995) Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus. J. Bacteriol. 177, 29422945.
  • 24
    Kanagasundaram, V. and Scopes, R.K. (1992) Cloning, sequence analysis, and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis. J. Bacteriol. 174, 14391447.
  • 25
    De Troch, P., Keijers, V. and Vanderleyden, J. (1994) Sequence analysis of the Azospirillum brasilense exoB gene, encoding UDP-glucose 4-epimerase. Gene 143–144.
  • 26
    Yamazaki, M., Thorne, L., Mikolajczak, M., Armentrout, R.W. and Pollock, T.J. (1996) Linkage of genes essential for synthesis of a polysaccharide capsule in Sphingomonas strain S88. J. Bacteriol. 178, 26762687.
  • 27
    Otten, S.L., Gallo, M.A., Madduri, K., Liu, X. and Hutchinson C.R. (1997) Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine. J. Bacteriol. 179, 44464450.
  • 28
    Kirschning, A., Bechthold, A. and Rohr, J. (1997) Chemical and biochemical aspects of deoxysugars and therefrom derived oligosaccharides. Topics Curr. Chem. 188, 184.
  • 29
    Summers, R.G., Wendt-Pienkowski, E., Motamedi, H. and Hutchinson, C.R. (1992) Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase. J. Bacteriol. 174, 18101820.
  • 30
    Rouch, D.A., Cram, D.S., DiBeradino, D., Littlejohn, T.G. and Skurray, R.A. (1990) Efflux mediated antiseptic resistance gene quacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. Mol. Microbiol. 4, 20512062.
  • 31
    Otten, S.L., Ferguson, J. and Hutchinson, C.R. (1995) Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus. J. Bacteriol. 177, 12161224.
  • 32
    Li, Y., Dosch, D.C., Strohl, W.R. and Floss, H.G. (1990) Nucleotide sequence and transcriptional analysis of the nosiheptide-resistance gene from Streptomyces actuosus. Gene 91, 917.