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The extracellular hyaluronidase gene (hylA) of Streptococcus pyogenes
Article first published online: 9 JAN 2006
DOI: 10.1111/j.1574-6968.2000.tb08999.x
1574-6968/asset/cover.gif?v=1&s=069bb2c224e243333d4486580fbd90d9ebeffa6b "FEMS Microbiology Letters")
Additional Information
How to Cite
Hynes, W. L., Dixon, A. R., Walton, S. L. and Aridgides, L. J. (2000), The extracellular hyaluronidase gene (hylA) of Streptococcus pyogenes. FEMS Microbiology Letters, 184: 109–112. doi: 10.1111/j.1574-6968.2000.tb08999.x
Publication History
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 13 January 2000, Accepted 18 January 2000
- Abstract
- Article
- References
- Cited By
Keywords:
- Hyaluronidase;
- Hyaluronate lyase;
- Streptococcus pyogenes
Abstract
Group A streptococci produce an extracellular hyaluronidase (hyaluronate lyase) which may be associated with the spread of the organism during infection. The gene for this hyaluronidase (hylA) encodes an 868 amino acid protein with a molecular size of 99 636 Da. Cleavage of the proposed signal peptide results in an extracellular protein of 95 941 Da. Comparison with other bacterial hyaluronidases indicates strong similarities to the genes from Streptococcus pneumoniae, Streptococcus agalactiae and Staphylococcus aureus. A region internal to the hylA gene was amplified from all 175 strains of Streptococcus pyogenes tested suggesting a widespread distribution of the gene.